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EasyFlex by 1MD is a revolutionary supplement containing three clinically studied ingredients, proven to promote optimal joint health. This groundbreaking formula combines Longvida® Optimized Curcumin, shown in clinical studies to both ease recovery after exercise and to be 285 times more bioavailable than 95% standardized curcumin, with WokVel® Boswellia Serrata, clinically researched to both support joint health and aid joint discomfort. EasyFlex also includes UC-II® brand collagen with undenatured type II collagen, a unique natural source of collagen clinically shown to perform significantly better than glucosamine + chondroitin for joint health and to support joint comfort, flexibility, and mobility.
Longvida® Optimized Curcumin
Powered by patented (US Patent 9192644, EP Patent 1993365; additional patents pending) SLCP™ Technology, Longvida® Optimized Curcumin is a breakthrough formula of the natural antioxidant curcumin, from the turmeric root. It is optimized to deliver free curcumin into target tissues through the critical bioavailability requirements of permeability, solubility, and stability. Developed in collaboration with elite neuroscientists at UCLA, Longvida® carries a strong safety profile and is self-GRAS.
Cutting-edge SLCP™ Technology, or Solid Lipid Curcumin Particle Technology, is responsible for the ‘magic’ of Longvida®. While this technology may be magical, in essence, it required a lot of hard work and brilliant insights to develop. Longvida® is a patented, finely-tuned lipophilic matrix brought together in a gentle, multi-step process. The end product preserves and protects the curcumin from the harsh environment of the stomach, dissolves it at the point of absorption in the GI tract, and delivers the free form of curcumin (also called intact or native curcumin) into the blood stream and target tissues. SLCP™ Technology is an ideal absorption-promoting system, based on repeatable research data using validated analytical methodologies.
WokVel® Boswellia Serrata
The sap from the Boswellia tree has been used for centuries in traditional Ayurveda medicine. In Sanskrit, its name Gajabhaksha, or ‘Elephant Tree’, may refer to the name Ayurvedic physicians gave it when witnessing elephants – symbols of longevity and strength – eating the sap from the tree bark. Commonly known as Frankincense (as a species), Boswellia resin holds a sacred place in the history of many cultures.
Representing the natural spectrum of boswellic acids used in traditional medicine for thousands of years, WokVel® is supported by peer-reviewed clinical trials. A major key to Boswellia’s effect on joint health is its bioavailability. In order to reduce inflammation, active boswellic acids must achieve target blood and tissue concentrations needed to address key enzymes such as 5-lipoxygenase (5-LO) responsible for joint function and flexibility.
UC-ll® Undenatured type II Collagen
UC-II® supplies collagen with undenatured type ll collagen for joint health support. It is manufactured in the United States through a patented, low-temperature, non-enzymatic process. Four clinical studies show that the benefits of 40 mg of UC-ll® are joint comfort, mobility and flexibility.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Why I Recommend EasyFlex by 1MD
As a Board Certified Cardiologist, I stand behind EasyFlex by 1MD which combines three clinically studied, patented ingredients, Longvida® Turmeric Curcumin, WokVel® Boswellia Serrata, and UC-ll® Undenatured type II Collagen, all clinically shown to boost systemic health.
Longvida® Optimized Curcumin uses a patented form of turmeric’s curcuminoids, which raises its bioavailability by 285 times, delivering free curcumin to targeted tissue, and eliminating the need for bioperine or other black pepper derivatives.
The other ingredient, WokVel®’s Boswellia Extract, was developed using a patented process that yields a highly bioavailable (standardized to 40% boswellic acids in naturally occurring ratios) form of the botanical without altering its nutrient profile.
UC-II® supplies collagen with undenatured type ll collagen through a patented, process and backed by clinical evidence proving it reduces knee discomfort, and is twice as effective as glucosamine and chondroitin.
In my opinion, 1MD has created the best joint health supplement on the market and I recommend EasyFlex to anyone looking to improve joint health, aid joint discomfort, elevate brain health, and boost energy levels and overall systemic relief in the body.
- Dr. Fenster, MD, FACC, FSCA&I
EasyFlex by 1MD is a daily supplement (60 capsules, 30-day-supply). As a dietary supplement, for optimal absorption take two (2) capsules on an empty stomach with a full glass of water in the morning. Those with sensitivity concerns may prefer to take with a small meal.
Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication, or have a medical condition. Discontinue use and consult your doctor if any adverse reactions occur.
KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
Non-dairy, non-GMO, gluten-free, soy-free, preservative-free, and sugar-free.
LONGVIDA® extract is patented under US 9192644 & EP 1993365 (other patents pending) and LONGVIDA® is a registered trademark of Verdure Sciences Inc.
WokVel® is a registered trademark of Verdure Sciences Inc.
UC-II® is a registered trademark of InterHealth N.I.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
I wanted to take turmeric for my brain health. My sister says she noticed a big difference so I ordered these. I definitely notice a difference. I feel more sharp and my memory seems better to me.
Most Effective Joint Product I've Used! These are super. I've heard about all the ingredients and that's enough to get me to start. I have found that this is the best supplement for my joints that I have tried!
Wow! Works Great! I like to stick with natural products.. My knees were acting up so I tried EasyFlex. The list of ingredients impressed me. After taking them, I can say they work like gangbusters!
I am pretty careful about what I buy. I want it to be safe. EasyFlex is backed by doctors and the ingredients are natural. That's a big plus for me. And they work!
Quality Ingredients. I am a label reader and was pleased with the ingredients of this -- turmeric for effectiveness, the other natural ingredients. I read about how turmeric can help with your brain as you get older and I have to say they work!
No Side Effects and Works! I have tried other supplements and felt this indigestion or that they didn't do much. With EasyFlex, no side effects at all and they work!
This supplement works! I like that it's made with natural ingredients that I've read about. I have RA and am careful with what I take but this seems safe and it works!
Excellent product! This really works on my stiff joints. I was having knee and hip pain so it was harder to move around. I wasn't looking forward to more extreme measures so I am glad this works!
A little pricey but worth it! I love EasyFlex. It's worth the cost because I can get around so much better. No more stiffness! And this weird thing happened. I notice my skin is looking a lot better and these brown spots on my hands are going away!
This is my lifeline! I don't know what I'd do without EasyFlex. I have tried them all but EasyFlex really gets my joints feeling better, less stiffness and no more aches. I also feel a lot more clear in my mind, more sharp. Not sure why but I'll take it!.
Super for joints! I used to get stuck on the couch for a few days after walking a lot But now that I've been taking these, I can get around way better!
Most amazing joint product! I've tried them all.I know that the ingredients are supposed to reallly work with arthritis. And I've got to say, I am impressed.
These works great! I am a jogger. Have been for years and I was afraid I'd have to stop because I'm 64. My knees and hips were bothering me. But after this, I'm as good as new!
Excellent product! I read about the ingredients before I ordered and I knew that turmeric and Boswellia were good for my osteoarthritis. And these work. I haven't noticed any side effects like I do with other things I have taken.
My husband and I started to take EasyFlex for those morning aches and that stiffness you get. It really works! We both feel alot better and to top it off, I feel like my skin is looking better. No more brown spots. .
I wanted something to help keep me sharp so I wouldn't constantly lose my keys or forget phone numbers LOL. So I heard that turmeric supplements could be good. I decided to order these and wow! I feel alot more on the ball!
Getting older doesn't have to be a problem! My sister was using turmeric just to remember more and to be in a better mood. I thought I'd try it out and I was surprised how quick this seems to work! I am sold!
I was having lunch with my friend when she said something looked different about me. I had just started taking this a week or so ago and I realized it was my skin! I was taking this for my joints and that works, too. But what a nice bonus!
I'm not the easiest sell. I am skeptical about everything but I was willing to give this a try. My knees and hips were just killing me all the time. I was shocked to see that it actually works,
I started to take these for my osteoarthritis -- but somehow, my skin looks better and I feel more on top of things! Win win!
Stiffness Gone! I've had trouble getting up and down the stairs, the usual problems. But now that I have been taking EasyFlex, no more!
I've always had osteoarthritis in my knees and it's been getting worse. I tried these and bam! They work!
I am not sure why but not only do my knees feel a lot better -- I have osteoarthritis -- but my skin looks a lot better. People have been noticing! Wow!
These are the best supplement I've tried for my RA. Hands down.
I wasted so much time and money over the years trying to do something about my knees. I didn't want to get surgery or anything like that. I was at the end of my road. I tried EasyFlex, not expecting much. I was surprised really at how much better I feel. No more stiffness. I actually feel younger.
Turmeric is supposed to be good for your brain as you get older so I throught I'd give it a try. These really work. I feel much more on top of everything.
This whole painful knee and hip thing has to go! It's hard not being able to get around like I used to. I tried shark cartilege, these other pills. I bought a knee brace, tried to stretch. Nothing worked. I've got to say that this works! I feel less stiff and it's not so hard to get up and down the stairs!
We're all looking for this magic elixir against the effects of aging. Well, Easy Flex has the whole joint stiffness thing covered. Now I need something to make me look 30 again!
It's always nice when you have extra benefits from a supplement! My osteoarthritis feels a lot better in my knees and even my knuckles and I also feel more alert!
This supplement really works! I think everyone who suffers from stiffness and those morning pains should give it a try. And I have noticed that these brown spots I was struggling with just vanished!.
Knee and hip pain is just the worst. Just walking up the stairs or trying to walk the dog is hard. I tried other things but nothing really did anything till I tried these. I swear, it's so much better! I feel alot better.
You know when you find something that actually works? You want to let everyone know. That's how I am feeling about EasyFlex. I was so frustrated with my rheumatoid arthritis but I am feeling an improvement.
I take turmeric to protect against cognitive issues since I'm getting up there so I ordered these and I've noticed a difference almost immediately. I'd recommend these.
I was okay taking these because they seemed natural or they had natural ingredients. I was thinking they'd help with my RA and I was right but I also notice my skin looks better. And I feel more on top of things.
It's not easy getting up there.The doctor says it's osteoarthritis.My knees were the first to go. It's gotten hard to just move around and I don't like it! I was not sure if it would work. I mean, these things never work But, I was surprised! I no longer have these aches and stiffness. And no side effects!
I've always been a pretty active guy. I played sports when I was younger. I really didn't like that I felt these aches and just couldn't do what I wanted. I try to use the treadmill or the bike in the gym but now, my knees were hurting.So I tried EasyFlex. Now, it's a lot easier for me to get to the gym and on the bike or treadmill. I'd recommend EasyFlex.
I read that taking turmeric was good for your brain to help with memory and things like that. So I started to take these and I noticed a definite improvement in how sharp I feel. It's amazing!
It's hard to say what it's like when you first notice all these aches and stiffness in joints. I thought it was just part of getting older, something I wasn't looking forward to. My family and friends were always wasting money on all these new things to help with that but it didn't seem to me that any of it worked. I am not sure what made me feel different about these but I decided to try it. And really, there's a big difference in how I feel. I've been telling my friends and family.
I'm not big on taking pills. Just don't like it. But my knees, hips, just about everything was achey and stiff. I tried these creams and lotions. Nothing did much. I bit the bullet and decided to go for EasyFlex. And I've got to say, I don't feel all achey and stiff. I don't love taking any pills still but it's worth it.
I'm 81 so I've been around for a while! I was an athlete. I still go to the gym a few times a week but for at least 25 years, my knees have been a problem. I didn't want to go for knee replacement or anything. So I would buy all this stuff I saw on TV. Nothing worked till I tried these. I swear, I feel so much better, like I am younger and can do much more.
These work great for my osteoarthritis in my knees. I could barely go up the stairs but now, it's not so hard!
I'm a grandma. I wanted to be able to play with my grandkids, take them to Disneyland but this stiffness and pains in my joints just made it hard. I couldn't get around like I used to do. So I tried this. I want to tell you that last week, I actually took the grandkids to Disneyland!
My mom and dad always complained about feeling stiff in the morning, getting around. I was surprised when it started to happen to me but I guessed that was the way it was. I tried different things. You know -- things I saw on TV. These new things they show over the years. I tried shark cartilege, all these supplements and lotions. Nothing did much till I tried this and it really works. It isn't just nonsense.
Since I turned 50 I think, all this standing on my feet at work has gotten to me. My knees just hurt and it was hard to get around. It's frustrating. I wasn't really expecting anything because nothing worked before. But it really worked.
I can't believe how this works for my RA. I am feeling a lot better!
I started to take this for my osteoarthritis but was so pleased to see that these brown spots I have seem to be vanishing! It's crazy! I'm really happy with this!
I was in pretty bad shape. I had to use a cane to help me out. I have arthritis in my knees, hips, sometimes I feel like it's everywhere. I tried all these things I bought at the drugstore or ordered. Supplements, shark cartilege, creams. Nothing was working. This has really helped with the pains and aches.
This is really helping with my joint stiffness from my osteoarthritis.. I didn't really want to take lots of NSAIDS and really, they weren't helping much when I did. I feel a lot less stiff now -- the only complaint I have is the taste from the supplements but it's not that bad!
For probably 10 years, I've been having these aches and pains in my joints, really everywhere from my osteoarthritis. My knuckles, knees. It was getting hard to go up and down the stairs. I decided to give this a try and wow! It really works. I don't feel those aches and pains any more and it's a lot easier to go up and down the stairs.
I used to wake up feeling stiffness in my joints. I tried some over the counter products and was taking anti-inflammatories but nothing helped. Once I tried EasyFlex, I now feel a huge difference! And I am happy that the ingredients are natural only better!
How often should I take EasyFlex?
As a dietary supplement, for optimal absorption take two (2) capsules with a full glass of water in the morning.
Should I take EasyFlex with a meal or on an empty stomach?
It is preferable to take this supplement on an empty stomach with a full glass of water in the morning. But, those with sensitivity concerns may prefer to take with a small meal.
What is difference between denatured and undenatured collagen?
Undenatured Type II collagen is considered native collagen that retains its biological activity and works in the small intestines through a process called tolerization. Unlike denatuerd collagen that can signal the immune system to attack cartilage, undenatured collage, like the one in UC-II® GOLD™ does not activate killer T-cells and helps minimize cartilage degradation in the joints.
What is the source of the active ingredients in UC-II®?
The active ingredient is UC-II® is undenatured Type II collagen which is sourced from chicken sternum cartilage.
How does SLCP Technology work to make curcumin 95 times more bioavailable?
SLCP™ TECHNOLOGY Cutting-edge SLCP™ Technology, or Solid Lipid Curcumin Particle Technology, is responsible for the ‘magic’ of Longvida®. While this technology may be magical, in essence, it required a lot of hard work and brilliant insights to develop. Longvida® is a patented, finely-tuned lipophilic matrix brought together in a gentle, multi-step process. The end product preserves and protects the curcumin from the harsh environment of the stomach, dissolves it at the point of absorption in the GI tract, and delivers the free form of curcumin (also called intact or native curcumin) into the blood stream and target tissues. SLCP™ Technology is an ideal absorption-promoting system, based on repeatable research data using validated analytical methodologies. Longvida® is free of harsh solvents and volatile oils.
Yes, but as always speak with your doctor before adding any new supplements to your routine.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Koronyo, Y et al. Retinal amyloid pathology and proof-of-concept imaging trial. JCI Insight. 2017. 2(16). DOI: 10.1172/jci.insight.93621 - Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective intervention. AD patients exhibit a myriad of retinal pathologies, including hallmark amyloid β-protein (Aβ) deposits.
Santos-Parker JR et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailiability and reducing oxidative stress. Aging. 2017 Jan. 3. Vol 9(No1): 187-208. A 12-week course of Longvida® (2000 mg/day) in healthy middle-aged and older adults demonstrated improved resistance artery endothelial function by increasing vascular nitric oxide bioavailability and reducing oxidative stress, while also improving endothelial function.
McFarlin et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. University of North Texas. BBA Clinical. 18 Feb 2016. 5: 72-78. DOI: 10.1016/j.bbacli.2016.02.003 - FIndings demonstrate that consumption of Longvida® (400mg/day) reduced inflammation during recovery after exercise-induced muscle damage with observed improvements in biological inflammation with potential to support faster recovery and improved functional capacity during subsequent exercise sessions.
Santos-Parker JR et al. Curcumin supplement improves vascular endothelial function in middle-aged and older adults. Geront. Dec 2015. 55(Suppl 2): 195. DOI:10.1093/geront/gnv554.01 - Longvida® administered at a dose of 2000mg/day or placebo for 12 weeks led to increased brachial artery flow-mediation dilation (FBDba) by 34% and forearm blood flow in response to incremental brachial artery infusions of acetylcholine (FBFach) by 44% in middle-aged or older adults. Findings support supplementation with Longvida improves endothelial-dependent dilation (EDD) in MA/O adults mediated, in part by an increase in nitric oxide bioavailability.
Rafii MS et al.The biomarker initiative DSBI pilot: Proof of concept for deep phenotyping of biomarkers. Front Behav Neurosci. 2015. 9: 1-11. - Longvida® provides the capacity to efficiently label retinal beta amyloid and to induce fluorescent plaque in the neural layers of the human retina, which is useful in deep phenotyping of Alzheimer’s biomarkers in Down’s Syndrome.
Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Centre for Human Psychopharmacology, Swinburne University. J Psychopharmacol. May 2015. (Vol 29) No 5: 642-651. DOI: 10.1177/0269881114552744 - Daily administration of Longvida® (400mg) led to significant improvements in cognitive function in measures of memory, attention, fatigue, stress, and mood as soon as one hour following dose in healthy subjects, aged 60-80 compared to a placebo.
Hazarey VK et al. Efficacy of curcumin in the treatment for oral |health.– A randomized clinical trial. Government Dental College and Hospital. Nagpur, Maharashtra, India. J Oral Maxillofac Pathol. 2015. 19: 145-52. DOI: 10.4103/0973-029X.164524 - Longvida® lozenges were demonstrated in a randomized, controlled clinical trial to be an effective combination strategy as opposed to a single therapeutic modality to manage OSF, as demonstrated by evaluation for mouth opening.
Frost S et al. Retinal amyloid fluorescence imaging predicts cerebral amyloid burden. Alz Dement. 2014. 10(4): P234-P235. - Longvida® ’s abiilty to cross the blood brain barrier and its affinity for binding to amyloid beta have led to its use and value as a more cost-effective alternative imaging tool for screening for Alzheimer’s biomarkers through the eyes, as retinal Aβ plaques are similar to plaques in the brain
Disilvestro et al. Diverse effects of a low-dose supplement of lipidated curcumin (as Longvida®) in healthy middle-aged people. The Ohio State University. Nutr. J. 2012 26;11:79 doi 10.1186/1475-2891-11-79 - At low-dosage, lipidated curcumin such as Longvida® demonstrated significant improvements in key biomarkers supporting cognitive, cardiovascular, and anti-aging among healthy subjects, as well as safety.
Khattry et al. Curcumin Decreases Cytokine Levels Involved in Mucositis in Autologous Transplant Setting: A Pharmacokinetic-Pharmacodynamic Study. American Society of Hematology. Atlanta, GA. 8 Dec 2012. Presentation. - Subjects evaluated after using Longvida® in lozenge form to address a common oral inflammatory and fibrotic condition showed significant improvement in contrast to the standard clobetasol steroid treatment. In addition, therapeutic plasma levels were detected, indicating buccal absorption.
Shah et al. Acute human pharmacokinetics of a lipid-dissolved turmeric extract. Planta Med. 2012. 78-PH5. - at doses as low as 200mg, Longvida® reaches blood levels of free curcumin associated with healthy brain aging. When blood samples were analyzed with and without the use of glucuronidase enzyme, very little of the glucuronidated form was found in blood, compared to earlier studies.
Pharmacokinetics of Longvida®: Dose-concentration correlation. Unpublished, UCLA 2011-2012 - Pilot studies demonstrating absorption and metabolism of Longvida® using various dosage forms.
Gota et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in patients and healthy volunteers. Tata Memorial Cancer Centre. J Ag Food Chem. 2010. 58(4): 2095-2099. - In a human bioavailability study, Longvida demonstrates significantly greater plasma levels of free (unconjugated) curcumin following a single dose in both healthy and diseased states with 65x greater Cmax and > 100x greater AUC than found in 95% curcuminoids.
Optimized Curcumin (Longvida®) binds to amyloid in human CNS after a single dose. Unpublished.
Evaluation of the safety and efficacy of Longvida® Optimized Curcumin in knee: A double-blind, placebo-controlled clinical trial. Bharati Vidyapeeth Deemed University, Pune, Ongoing
A phase 1 open-label prospective cohort trial of Curcumin plus Tyrosin Kinase Inhibitors for EGFR-mutant advanced NSCLC. McGill U & Jewish General Hospital, Canada, Ongoing.
Curcumin and Yoga Exercise Effects in Veterans at Risk. ULCA, Ongoing.
Longvida Cases Reports 2008-2013. Verdure Sciences, Unpublished data. - A large base of anecdotal evidence has supported the clinical findings for Longvida’s benefits for a wide range of neurological, inflammatory and age-related health concerns.
Taylor, University of Colorado. 2010. Case Report, Nursing Graduate Thesis. - Longvida® lowered toxic levels of mucopolysaccharides in a 10-year old female with Sanfillippo Syndrome, an effect thought related to the calcium channel modulating and anti-inflammatory effects of Longvida.
Tata Memorial Cancer Centre, Mumbai. Preliminary data and case reports. - Pilot study in 11 terminal-stage patients resulted in improvements quality of life measures including pain, nausea and appetite, and has led to wide usage of Longvida in patients in India and worldwide.
Effects of Longvida®: human case studies. Fish, 2010. Case Reports. - Widespread physician use of Longvida in children with has led to several case reports observing rapid improvement in cognitive function and learning ability. Humans exhibit high neuroinflammation and amyloid-beta accumulation from an early age.
Longvida improves cognitive function in patients with neurodegenerative disorders. Unpublished survey data. - 74% of subjects reported improvements in cognitive function in a computerized survey of 58 respondents (patients and caregivers) ages 2 to 90 taking Longvida daily.
Liu W et al. Development of a neuroprotective potential algorithm for medicinal plants. University of Rhode Island. Neurochem Int. 29 Sep 2016. 100: 164-177. - As part of a strategy to help guide the selection and evaluation of medicinal plant candidates for their neuroprotective potential, researchers at the University of Rhode Island developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation.
Nam DE et al. Effect of Boswellia serrata extract on degenerative OA in invitro and in vivo models. J Korean Soc Food Sci Nutr. 2014 Apr 2. 43(5). DOI: http://dx.doi.org/10.3746/jkfn.2014.43.5.페이지 - In a study of the effect of Boswellia serrata extract on degenerative osteoarthritis, WokVel® was found to mediate articular cartilage degeneration through prevention of extracellular matrix degradation and chondrocyte injury, significantly reducing and normalizing the production of pro-inflammatory biomarkers. In addition, WokVel® Extract significantly reduced 5-LOX activity and production of PEG2. Researchers concluded that “one can consider that extract may be a potential therapeutic treatment for degenerative .”
REVIEW: Ernst E. Frankincense: Systematic review. BMJ. 2008 Dec 18. 337: a2813. DOI: 10.1136/bmj.a2813 - Summary and review of various clinical trials on Boswellia serrata with mentions of WokVel® clinicals included.
Sontakke S et al. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in OA of knee. Indian J Pharmacol. 2007 Feb. Vol 39(Issue 1): 27-29. - Compared to the nonsteroidal anti-inflammatory drug valdecoxib, WokVel® exhibited a slower onset but persistent effectiveness even after discontinuation to address osteoarthritis of the knee. The action of the NSAID quickly dissipated after stopping treatment in the study, which tracked efficacy, safety, and tolerability of WokVel® compared to an NSAID.
Sharma S et al. Pharmacokinetic study of 11-keto β-boswellic acid. Phytomedicine. 2004 Feb. 11: 255-260. - A single 333mg dose of WokVel® led to plasma concentrations of 11-keto-boswellic acid (KBA), demonstrating WokVel’s capacity to address the pro-inflammatory cytokine 5-lipoxygenase. WokVel® was shown to be safe and well tolerated.
Kimmatkar N et al. Efficacy and tolerability of Boswellia serrata extract in treatment of OA of knee – A randomized double blind placebo controlled trial. Phytomedicine. 2003. 10:3-7. - Subjects receiving WokVel® reported decreased knee pain, increased knee flexion, and increased walking distance. The observed differences between WokVel and a placebo were reported as statistically significant and clinically relevant following an 8-week randomized double blind placebo controlled study of 30 subjects.
Gota P et al. Comparison of the Metabolic Stability of Solid Lipid Boswellia Serrata Particles Versus Plain Boswellia Serrata Extract in Human Hepatocytes (HHL-17). Int J Pharm Chem Biol Sci. 2016. 6(1): 22-27. - With reported extremely low hepatic clearance of AKBA and conferred metabolic stability of KBA in this study, WokVel® SLP™ may have enhanced oral bioavailability of KBA and AKBA compared to Boswellia serrata extract. In an in vitro study in human hepatocytes HHL-17, WokVel® SLP™ (Solid Lipid Particle) exhibited lesser accumulation of KBA in hepatocytes and low metabolic clearance.
UC-II® Nutrition Journal 201615:14 DOI: 10.1186/s12937-016-0130-8. © Lugo et al. 2016. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms. UC-II improved knee joint symptoms in knee OA subjects and was well-tolerated following a multicenter randomized, double-blind, placebo controlled study. Undenatured type II collagen (UC-II) derived from chicken sternum cartilage was evaluated for efficacy to address knee osteroarthritis pain and associated symptoms, as well as tolerability, compared to a placebo and to glucosamine hydrochloride plus chondroitin sulfate.
UC-ll® PubMed. Int Soc Sports Nutr. 2013. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK1 - Daily supplementation with 40 mg of UC-II was well tolerated and led to improved knee joint extension in healthy subjects. UC-II also demonstrated the potential to lengthen the period of pain free strenuous exertion and alleviate the joint pain that occasionally arises from such activities.
UC-ll® PubMed Int J Med Sci. 2009 Oct 9;6(6):312-21. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee. The results of a clinical trial indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in a glucosamine and chondroitin treatment group for osteoarthritis of the knee.
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