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Sharpen Your Mind: The Brain-Boosting Benefits of Phosphatidylserine

Can phosphatidylserine supplements really improve memory, concentration, mood, and neurological function? Get the science-based facts right here.

By 1MD Nutrition Editorial Staff

0 minute read

Last Updated December 15, 2023

Phosphatidylserine: The Brain-Boosting Supplement

In the quest for optimal cognitive health, many people turn to supplements to gain an extra edge. MindMD™ is one such supplement, and phosphatidylserine is just one of the powerhouse ingredients found in MindMD™ that has gained popularity in recent years. The most researched-backed nootropic for long-term memory, phosphatidylserine is a critical building block of cell membranes, particularly in brain cells. It’s renowned for supporting cognitive function, including memory, focus, and overall cognitive performance. As a safe and 100% naturally derived ingredient, phosphatidylserine holds tons of promise in promoting cognitive well-being.

What is Phosphatidylserine?

Phosphatidylserine, sometimes referred to as PS, is a naturally occurring phospholipid compound and a vital component of cell membranes, particularly in the brain. Phospholipids are a type of lipid that includes phosphorus, an essential mineral. Phosphorus plays a crucial role in the formation and maintenance of bones, teeth, and DNA. On the other hand, phosphatidylserine plays a key role in cell cycle signaling, or cellular communication and signaling, making it crucial for proper brain function. In addition, phosphatidylserine helps regulate neurotransmitters, the chemicals responsible for transmitting messages between nerve cells in the brain.

The brain's natural production of phosphatidylserine can decrease as we age for a number of reasons, such as normal, age-related changes in metabolic processes, hormonal fluctuations, and the overall decline in cellular function. This decline has led to research on how phosphatidylserine can work as a potential strategy to support cognitive health in aging individuals.

Combined with Bacopa monniera, a traditional Ayurvedic herb known for its memory-supporting properties, the two can work together to promote everyday brain function and memory formation. Additionally, vitamin B6 and folate are essential nutrients that support the production of red blood cells and neurotransmitter synthesis, allowing for better communication between brain cells and boosting mental clarity. Green tea leaf and grape extract are both rich in powerful antioxidants and polyphenols that have been shown to have neuroprotective effects, reducing oxidative stress in the brain. This combination found in MindMD™ provides comprehensive support for cognitive function and overall brain health.

Where Does Phosphatidylserine Come From?

Phosphatidylserine is a phospholipid naturally found in our bodies and can also be obtained through dietary sources. The main dietary sources of phosphatidylserine include fish, soy, and sunflowers. Fish, such as mackerel and herring, are particularly rich in phosphatidylserine. Soy products, like tofu and soybeans, are also good sources. Additionally, sunflower seeds and sunflower oil contain phosphatidylserine in smaller amounts.

However, it’s important to note that obtaining sufficient amounts of phosphatidylserine solely through diet can be challenging. This is where supplementation can be beneficial. MindMD™ provides a convenient and reliable way to ensure an adequate intake of phosphatidylserine for optimal cognitive and brain health.

In addition to dietary sources, phosphatidylserine can also be produced synthetically. Synthetic phosphatidylserine is derived from plant-based sources and undergoes a purification process to ensure its quality and safety. The synthetic form of phosphatidylserine used in MindMD™ is carefully selected to meet the highest standards of purity and efficacy.

By including phosphatidylserine in MindMD™, 1MD Nutrition® aims to provide customers with a comprehensive formula that supports cognitive function and brain health. The inclusion of phosphatidylserine and other carefully selected ingredients is based on scientific research and evidence supporting their potential benefits for cognitive performance.


The Brain-Supporting Benefits of Phosphatidylserine

Phosphatidylserine plays a crucial role in maintaining the integrity of brain cell membranes, facilitating efficient communication between nerve cells and the release of neurotransmitters. 

Phosphatidylserine has also shown a positive impact on mood, reducing symptoms of everyday stress and alleviating brain fog. 

By including phosphatidylserine in MindMD™, 1MD Nutrition® provides a comprehensive formula that supports optimal brain function and cognitive performance, and here are insights into the specific usefulness of this naturally derived nootropic:

Promotes Memory, Learning, Concentration, Recall

Phosphatidylserine has been extensively studied for its potential to enhance cognitive function, particularly memory, learning, concentration, and recall. Research suggests phosphatidylserine supplementation may support memory and cognitive performance in people experiencing age-related cognitive decline or memory impairment. It has also shown promise in memory and cognitive maintenance.

Phosphatidylserine plays a crucial role in maintaining the integrity and functionality of brain cell membranes. 

Supporting the fluidity and permeability of these membranes facilitates efficient communication between brain cells, which is essential for optimal cognitive function. This improved communication can promote memory formation, learning abilities, and overall cognitive performance.

Supports Nerve Cell Communication

Neurotransmitters play a vital role in various cognitive processes, including mood regulation, memory formation, and attention. 

Phosphatidylserine helps maintain the balance and availability of neurotransmitters, such as acetylcholine, dopamine, and serotonin, essential for optimal brain function. By supporting the release and activity of these neurotransmitters, phosphatidylserine can support cognitive abilities, promote mental clarity, and benefit overall brain health.

May Promote Mood and Ease Brain Fog

In addition to its cognitive benefits, phosphatidylserine also has a positive impact on mood and brain fog. 

Research suggests that phosphatidylserine supplementation may help reduce symptoms of everyday stress by maintaining healthy cortisol levels in the body, whether from everyday emotional stress or physical exertion (such as intense workouts). 

Phosphatidylserine has also been shown to reduce brain fog, a condition characterized by difficulty concentrating, mental fatigue, and a lack of mental clarity. 

By supporting brain cell membrane function and neurotransmitter release, phosphatidylserine can help support focus, attention, and overall cognitive performance, leading to a clearer and more alert mind. 

Reducing the symptoms of everyday stress, which can exacerbate a feeling of exhaustion, also contributes to reduced brain fogginess. 

Clinical Research

Phosphatidylserine has garnered significant attention in clinical research for its impact on cognitive function. 

Numerous studies have explored the efficacy of phosphatidylserine supplementation in supporting brain health, especially among people within the age range of 50-70, a pivotal time when cognitive changes may arise. 

Studies have shown promising results, suggesting phosphatidylserine supplementation may help mitigate common, age-related cognitive decline, boost focus, and support mental clarity. 

This comprehensive body of research underscores the potential benefits of phosphatidylserine, reinforcing its role as a significant ingredient in the meticulously formulated cognitive health supplement MindMD™. 

Proper Dosage: How Much Should You Take?

The recommended dosage of phosphatidylserine for cognitive and brain health typically ranges from 100 mg to 400 mg per day. 

It’s always important to speak with your doctor before starting any supplement, especially if you are currently taking any blood-thinning medications, are pregnant or nursing, or are about to or have had surgery. 

The dosage may vary depending on age and the specific condition being treated. It’s important to adhere to the recommended dosage and avoid overconsumption to minimize the risk of potential side effects that include gastrointestinal discomfort, such as upset stomach or diarrhea. 

By following the proper dosage guidelines, you can maximize the benefits of phosphatidylserine supplementation and support your cognitive and brain health effectively.

Finding a Quality Phosphatidylserine Supplement

When looking for a quality phosphatidylserine supplement, there are a few key factors to consider to ensure you are getting a reliable and effective product. Here are some guidelines to follow:

Look for reputable brands: Choose a supplement from a reputable and trusted brand. Look for companies that have a good track record and adhere to strict quality control standards.

Check for third-party testing: Look for supplements that have undergone third-party testing for quality and purity. This ensures the product has been independently verified for its ingredients and potency.

Opt for clinically studied forms: Phosphatidylserine supplements come in different forms, such as soy-based or sunflower-based. Though it looks promising, there is not yet enough research into the benefits of sunflower-based phosphatidylserine — in terms of bioavailability and stability compared to soy-based forms. Look for supplements that use soybean-derived phosphatidylserine.

Read the label: Carefully read the product label to ensure the supplement contains an adequate phosphatidylserine dosage. The label should clearly state the amount of phosphatidylserine per serving.

Be wary of too many additives: Some supplements may contain unnecessary additives, fillers, or artificial ingredients. It’s best to choose a supplement with minimal additives and a clean ingredient list.

By following these guidelines, you can increase the likelihood of finding a quality supplement containing phosphatidylserine that meets your needs.

Precautions and Potential Side Effects

Phosphatidylserine is generally well-tolerated, but some people may experience mild gastrointestinal upset, such as stomach discomfort, bloating, or diarrhea. If these symptoms occur, reducing the dosage or discontinuing use and consulting with a healthcare professional is advisable. 

Additionally, phosphatidylserine may interact with certain medications, particularly those that affect blood clotting or anticoagulant therapy. It is important to exercise caution and consult with a healthcare professional before starting phosphatidylserine supplementation if you are taking any medications.

Limited data is available on the safety of phosphatidylserine during pregnancy and breastfeeding, so it’s generally recommended to avoid supplementation during these periods. 

People with known allergies to soy should also be cautious, as some forms of phosphatidylserine contain this allergen. Remember that a healthcare provider can provide personalized guidance based on your specific circumstances and help you make an informed decision regarding the use of phosphatidylserine.

Frequently Asked Questions


What are the main benefits of taking phosphatidylserine?

Phosphatidylserine offers a range of potential benefits that make it a valuable addition to your cognitive supplement routine. Research suggests phosphatidylserine can support memory, attention, and overall cognitive performance.* By promoting communication between brain cells, supporting neurotransmitter production, and protecting against age-related cognitive decline, it helps keep your mind sharp and focused.* Phosphatidylserine has also been found to support healthy cortisol levels, a hormone associated with stress, thereby reducing everyday stress and boosting mood.* While individual results may vary, incorporating phosphatidylserine into a daily, long-term routine may help unlock your cognitive potential and support your overall well-being. As always, it's best to consult a healthcare professional to determine the right approach for your specific needs.

Who is phosphatidylserine recommended for?

Phosphatidylserine is recommended for people who are looking to support their cognitive function. It can be particularly beneficial for adults between the ages of 45 through 70, when cognitive changes may become noticeable. If you find yourself struggling with memory, attention, or overall cognitive performance, phosphatidylserine may be a valuable addition to your cognitive routine. 

Is phosphatidylserine safe for long-term use?

Phosphatidylserine is generally considered safe for long-term use when taken at recommended dosages. As a matter of fact, the benefits are best achieved when taken consistently and on a long-term basis. However, it's always a good idea to consult with a healthcare professional before starting any new supplement, especially if you have underlying health conditions, are taking medications, or plan on taking a supplement longer than three months. 

How long does it take for phosphatidylserine to start working?

This can vary from person to person. While some people may notice the benefits within a few weeks, others may require several months of consistent use to experience noticeable benefits. It's important to remember that phosphatidylserine is not a quick fix but rather a supplement that supports long-term cognitive health. Always take phosphatidylserine as part of a daily, consistent routine and combine it with a healthy lifestyle that includes regular exercise, a balanced diet, and adequate sleep to maximize its effectiveness. Patience and consistency are essential when it comes to reaping the full benefits of phosphatidylserine.

Should I take phosphatidylserine with food or on an empty stomach?

Phosphatidylserine can be taken with or without food, as it’s generally well-absorbed by the body. However, some people may find that taking it with a meal helps to minimize any potential gastrointestinal discomfort. If you experience digestive issues when taking phosphatidylserine on an empty stomach, try taking it with a meal or snack. Ultimately, choosing to take it with or without food depends on your preference and how your body responds. Just remember to follow the recommended dosage and be consistent in your routine for optimal results.

The Bottom Line

Phosphatidylserine is a safe and naturally derived key ingredient that can significantly boost brain power and support cognitive function. Incorporating cognitive support supplements containing phosphatidylserine, like 1MD Nutrition's MindMD™, into your daily health regimen makes an invaluable contribution toward your long-term health goals. There’s no better day to start your journey towards improved cognitive health than today.