David Kahana, MD, CPNS
Gastroenterology & Medical Nutrition
Dr. Kahana, a board-certified gastroenterologist, is a trusted expert in liver health and science-backed wellness solutions.
Dr. Kahana reveals the top liver supplements for health and detox in 2025
Top GI Doctor uncovers how targeted liver support tackles common symptoms and why most supplements miss the mark.
Medically Reviewed
Fact Checked
Patient-Focused
Written by
David Kahana, MD, CPNS
Gastroenterology & Medical Nutrition
Past-President, National Board of Physician Nutrition Specialists
11 Jan 2022 • 5 min read
Millions of people across the U.S. have been looking for a solution to cleanse their liver from the effects of alcohol use and overprocessed foods. With no clinically studied solutions available, it’s no wonder that the liver supplement market has been growing exponentially. However, finding the right liver supplement can be overwhelming.
As a gastroenterologist with over 20 years of clinical experience, I’ve evaluated the market to identify what truly works. Most products fall short of the gold standard for ingredient quality and effective dosages. This guide highlights the best options that deliver real, powerful results.
Let’s dive in—you’re about to discover the breakthrough your health has been waiting for.
Key Benefits of a Quality Liver Supplement
Supports long-term liver health
Detoxifies and repairs the liver
Reduces oxidative stress at a cellular level
Delivers a measurable improvement to your liver panel results
Common Habits Negatively Affecting Your Liver Health
Consuming Alcohol
Eating a High-Fat or Processed Diet
Skipping Regular Exercise
Overusing Pain Relievers or Medications
Ignoring Signs of Stress or Poor Sleep
The Shocking Truth About Liver Detox Drinks—and What Actually Works
- Most are marketing hype, not science.
- Many products lack clinical backing.
- These fads may strain your liver.
- Focus on long-term care, not quick fixes.
- Find the right liver supplement for you.
- Opt for doctor-formulated solutions.
- Pair healthy supplements with good lifestyle choices.
How To Choose the Best Liver Supplement in a Market Full of Hype
With so many options on the market, it’s easy to feel overwhelmed by flashy claims and questionable ingredients. Many supplements lack real science, offering more fluff than substance.
Uncover The Truth
- A high-quality liver supplement makes a real difference when it contains clinically studied ingredients in the right dosages.
- Focus on products that avoid unnecessary fillers and prioritize proven results.
- A great product has a proven reputation and can measurably improve liver health
Fatigued? Bloated? Your Liver Might Be to Blame
Feeling wiped out despite getting plenty of rest?
It could be a sign that your liver is struggling.
As your body’s detox powerhouse, your liver plays a critical role in:
- Clearing toxins
- Absorbing nutrients
- Maintaining energy levels
When overworked or under-supported, you might notice a sharp dip in energy, persistent bloating, or even a sense of heaviness.
The good news?
The right liver supplement, combined with healthy habits, can help restore balance and give you back the vitality you’ve been missing.
It’s all about finding the ultimate solution tailored to your needs.
When Will You See Results?
Improving liver health is a long-term commitment that requires consistency, patience, and healthy lifestyle choices.
With regular use of a high-quality liver supplement, combined with balanced nutrition and exercise, your liver can detoxify, repair, and function at its best.
You may feel less discomfort as liver-nourishing nutrients start to tackle bloating and soothe your digestive system.
As your overall liver health starts to improve, don’t be surprised if you notice more energy and a better mood.
This is when peak support officially begins. In fact, some people report feeling a "night-and-day" difference with long-lasting digestive comfort, better weight management, and less brain fog.
Doctor’s Tip:Consistency is key. So, make sure to stick with a quality formula for at least 3 months, but ideally 6 months or more.
With all of these health benefits in mind, which ingredients should you look for in a liver supplement, and what should you avoid?
The Ultimate Ingredient Checklist for Liver Supplements
Nearly all available supplements we looked at DO NOT contain the effective dosages of the below ingredients:
NAC helps reduce oxidative stress in the liver to keep your immune system, cells, and tissues in check. It’s also a basic building block of glutathione, which has been called “the mother of all antioxidants.” You can find it in a variety of meats, seafood, and turkey.
Tocotrienols are a very potent form of vitamin E, or as we like to call them, supercharged vitamin E. This powerhouse ingredient can work to help cleanse your liver of typical fat buildup.
Recent research has shown that milk thistle can help reduce irritation caused by everyday oxidative stress and toxins. It can also help support liver function, thus helping your metabolic process run more efficiently and help healthy weight management.
Various studies have shown that zinc can help protect your liver from future stress, by reducing the lipid (or fat) buildup in your liver.
This powerful mineral is vital for helping your liver cleanse and detox itself. It’s able to help your liver detox from unhealthy buildup by encouraging the production of an antioxidant called glutathione, which can help support healthy liver tissue cells and promote elasticity.
Avoid These Common Filler Ingredients
Often used as a flow agent in supplements, it may interfere with nutrient absorption and isn’t necessary for effective formulations.
A whitening agent with no health benefits, it’s linked to potential safety concerns and is best avoided in supplements.
A cheap filler that can spike blood sugar levels, offering no nutritional value or benefit to liver health.
Commonly used for capsules, it’s derived from animal sources and may not align with dietary preferences like vegan or vegetarian lifestyles.
Disclaimer: The following content is based on the featured product’s website claims, current as of December 2024.
Given my strict criteria and exhaustive research, I could not find a meaningful solution available on the market. That’s why I decided to team up with 1MD Nutrition to develop a clinically effective solution that meets expectations for targeted liver support.
After extensive research, we developed a truly effective formula that has won multiple awards and helped millions achieve optimal liver health. We call it LiverMD. Now, I am confident that those looking for comprehensive liver support will get the best ingredients at the most clinically effective doses. The results speak for themselves:
- Over 80% saw significant improvements on liver test results
- 92% experienced smoother digestion*
- 90% felt less bloated*
- 91% had reduced brain fog*
- Over 1.5 million bottles sold
Notably, LiverMD has been recognized for its excellence, winning the 2021 Taste for Life Essentials Supplement Award for Best Liver Support Supplement and the 2023 Delicious Living Supplement Award in the Cleanse & Detox category.
Backed by clinical research and trusted by health professionals, it's the supplement I confidently recommend to my patients for achieving real, measurable results.
The 5 Best Liver Supplement Picks for 2025
Below are my final rankings from years in gastroenterology, which I know will help you to make an informed and quality decision:
1. LiverMD®
A+
OVERALL GRADE
Pros
-
Physician-Formulated
-
Clinical Ingredient Dosages
-
Supports daily detoxification
-
Promotes Glutathione Production
-
Reduces Oxidative Stress
-
Encourages everyday cellular repair
-
Includes Vitamin E, Milk Thistle, NAC, ALA, and Zinc
-
Transparent ingredient list
-
Get 10% off with code 'First10'
Cons
-
Frequently out of stock
The Bottom Line
Backed by clinical research and trusted by health professionals, LiverMD® stands out in a crowded market. Over 80% of users report significant improvements in liver test results, with smoother digestion, reduced bloating, and less brain fog, among its proven benefits. Recognized with awards like the 2024 Alive Award Bronze - Favorite Detox Product and the 2023 Delicious Living Supplement Award, it remains the gold standard in liver health.
With over 1.5 million bottles sold and a 90-day money-back guarantee, LiverMD® offers a trusted, results-driven solution for those seeking lasting improvements in liver health and overall well-being. This isn’t just another supplement—it’s the only one designed to meet the highest clinical standards and deliver real, measurable results.
Key Benefits:
- Over 80% saw significant liver test improvements.
- 92% experienced smoother digestion.*
- 90% felt less bloated.*
- 91% noticed reduced brain fog.*
Why Choose LiverMD®?
- Doctor-formulated with clinical ingredient dosages.
- Promotes detoxification, energy, and cellular repair.
- Better liver panel results guaranteed
- Free of fillers like magnesium stearate and titanium dioxide.
A
OVERALL GRADE
Pros
-
Meaningful Ingredient Dosages
-
Supports daily detoxification
-
Reduces oxidative stress
-
Encourages everyday cellular repair
-
Includes Milk Thistle, NAC, ALA, and Zinc
-
Vegan-friendly, gluten-free, and free of synthetic fillers
-
Transparent ingredient list
-
Affordable price point
Cons
-
Limited ingredient variety
-
Significantly more expensive
The Bottom Line
LiverWell by Live Conscious® is designed to support liver health with a simple but effective formula. Its inclusion of clinically studied ingredients like milk thistle and selenium makes it a reliable choice for promoting detoxification and reducing oxidative stress.
This supplement is especially beneficial for those looking for a no-fuss approach to maintaining liver health while also boosting energy levels. Its formula is gluten-free and avoids unnecessary fillers, ensuring quality and safety.
While LiverWell is effective, its ingredient variety is somewhat limited compared to other products. Those seeking a broader blend of active components might find other options more appealing.
*Can be purchased at Walmart
3. Dose for Your Liver
byDose
B
OVERALL GRADE
Pros
-
Supports daily detoxification
-
Reduces oxidative stress
-
Encourages everyday cellular repair
-
Includes Milk Thistle
-
USDA Organic
Cons
-
3X the price of our #1 choice with no additional benefits
-
Undisclosed ingredient dosages
-
Limited ingredient variety
The Bottom Line
Dose for Your Liver is one of the more prominent names in the liver health supplement market, but its price leaves much to be desired. Dose for Your Liver costs 3-4 times more than comparable products, making it far less accessible for those seeking affordable liver health solutions. As a larger brand, it has gained attention for its use of turmeric and other plant-based ingredients, although its offerings remain limited in variety and transparency.
Its proprietary blend also lacks transparency regarding ingredient dosages, which may leave consumers unsure about the formula's true effectiveness. Additionally, its limited ingredient variety may not provide the comprehensive liver support needed for individuals with more advanced health concerns.
For those on a budget or looking for clinically proven, cost-effective options, there are better alternatives available.
*Can be purchased at Walmart
4. Liver Cleanse
B-
OVERALL GRADE
Pros
-
Supports daily detoxification
-
Reduces oxidative stress
-
Encourages everyday cellular repair
-
Includes Milk Thistle
-
Vegan-friendly, gluten-free, and free of synthetic fillers
-
Reputable brand for herbal products
Cons
-
Undisclosed ingredient dosages
The Bottom Line
Gaia Herbs®’ Liver Cleanse takes a natural, herbal-based approach to liver health. It includes ingredients like dandelion and artichoke, known for their ability to promote digestion and detoxification.
The product is vegan, gluten-free, and made with naturally sourced herbs, appealing to environmentally conscious consumers. Its reputation as a trusted herbal brand adds to its credibility.
That said, its formula is less comprehensive than others on the market that offer transparent ingredient dosages, rather than a protected proprietary blend. It’s best suited for those seeking a gentle, herbal approach to liver support.
*Can be purchased at Walmart
5. Liver Support
C+
OVERALL GRADE
Pros
-
Meaningful Ingredient Dosages
-
Supports daily detoxification
-
Reduces oxidative stress
-
Encourages everyday cellular repair
-
Includes Milk Thistle
-
Vegan-friendly, gluten-free, and free of synthetic fillers
-
Transparent ingredient list
-
Affordable price point
Cons
-
Limited customer reviews
The Bottom Line
Liver Support by Vital Nutrients offers a comprehensive formula with clinically backed ingredients like Milk Thistle Extract.
The supplement is free from gluten and dairy, catering to individuals with dietary sensitivities. Its commitment to quality and clinically tested components gives it a reliable edge on many other options in the market.
However, its limited product reviews may be a drawback for some consumers. Despite its efficacy, those seeking more feedback might look for alternatives with a stronger review presence.
*Can be purchased at Kroger
About 1MD Nutrition®
1MD Nutrition® is a trusted leader in health and wellness, providing clinically-backed, physician-formulated supplements designed to address today’s most pressing health concerns. With a medical advisory board of board-certified specialists in cardiology, gastroenterology, and immunology, every product is crafted with science-driven precision to ensure maximum safety and efficacy.
Recognized with prestigious awards like the Taste for Life Essentials and Delicious Living Supplement Awards, 1MD Nutrition has earned its reputation for quality and results. Our supplements have improved the lives of over 1 million satisfied customers, addressing needs from digestive health to immune support with unmatched reliability.
Beyond products, 1MD Nutrition partners with leading institutions and supports charitable initiatives to promote better health worldwide. This commitment reflects our mission to deliver real, measurable wellness solutions that stand apart from the rest.
Dr. Kahana also volunteers as a medical consultant for a non-profit organization called What’s In Your Lunchbox (WIYLBox) and as a medical provider for a specialty camp for children with chronic illnesses called The Painted Turtle Camp. Dr. Kahana was recently elected to be the Treasurer/Secretary of the Board of Directors for the National Board of Physician Nutrition Specialists. He also sits on the Nutrition Committee for the Providence Hospital Network, where he is helping establish a nutrition program for patients with IBD.
American Academy of Pediatrics (AAP)
American Medical Association (AMA)
American Society for Parenteral and Enteral Nutrition (ASPEN)
North American Society for Pediatric Gastroenterology Hepatology and Nutrition (NASPGHAN)
American Gastroenterology Association (AGA)
American College of Gastroenterology (ACG)
Crohn’s and Colitis Foundation of America (CCFA)
